Modeling of bacterial lipopolysaccharide-induced endometritis in rats and the possibility of its therapy using plasma enriched with soluble platelet factors

We presents results of a study on endometritis modeling in rats with double intravaginal administration bacterial lipopolysaccharide (LPS). The established endometrial inflammatory process was accompanied by decrease the weight animals, an increase uterus, neutrophilic infiltration, edema, and overexpression cyclooxygenase endometrium 30-45 days after start induction. Local use plasma enriched soluble platelet factors/platelet-rich (PORFT/PRP) caused intensity rate neutrophil infiltration endometrium, cyclooxygenase, interleukin-6 transforming growth factor-β expression, body animals. conclusion made possibility creating model LPS ability local PORFT/PRP to have therapeutic effect endometrium.